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1

A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism

Berndt, Nikolaus, Horger, Marius Stefan, Bulik, Sascha, Holzhütter, Hermann-Georg, Beard, Daniel A.

Journal:

PLoS Computational Biology

Year:

2018

Language:

english

File:

PDF, 5.69 MB

english, 2018

2

Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism

König, Matthias, Bulik, Sascha, Holzhütter, Hermann-Georg, Papin, Jason A.

Journal:

PLoS Computational Biology

Year:

2012

Language:

english

File:

PDF, 1.99 MB

english, 2012

3

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

Borchert, Astrid, Kalms, Jacqueline, Roth, Sophia R., Rademacher, Marlena, Schmidt, Andrea, Holzhutter, Hermann-Georg, Kuhn, Hartmut, Scheerer, Patrick

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2018

Language:

english

File:

PDF, 11.15 MB

english, 2018

4

The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity

Kalms, Jacqueline, Banthiya, Swathi, Galemou Yoga, Etienne, Hamberg, Mats, Holzhutter, Hermann-Georg, Kuhn, Hartmut, Scheerer, Patrick

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

5

Uncovering Metabolic Objectives Pursued by Changes of Enzyme Levels

Sabrina Hoffmann, Hermann-Georg Holzhütter

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 517 KB

english, 2009

6

A mathematical model to study short-term regulation of mitochondrial energy transduction

Hermann-Georg Holzhütter, Wolfgang Henke, Wolfgang Dubiel, Gerhard Gerber

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1985

Language:

english

File:

PDF, 1.14 MB

english, 1985

7

Assessment of Proteasomal Cleavage Probabilities from Kinetic Analysis of Time-dependent Product Formation

Björn Peters, Katharina Janek, Ulrike Kuckelkorn, Hermann-Georg Holzhütter

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 744 KB

english, 2002

8

Rapid degradation of solid-phase bound peptides by the 20S proteasome

Hovestädt, Marc, Kuckelkorn, Ulrike, Niewienda, Agathe, Keller, Christin, Goede, Andrean, Ay, Bernhard, Günther, Stefan, Janek, Katharina, Volkmer, Rudolf, Holzhütter, Hermann-Georg

Journal:

Journal of Peptide Science

Year:

2013

Language:

english

File:

PDF, 653 KB

english, 2013

9

A Conceptual Mathematical Model of the Dynamic Self-Organisation of Distinct Cellular Organelles

Binder, Bernd, Goede, Andrean, Berndt, Nikolaus, Holzhütter, Hermann-Georg, Secomb, Timothy W.

Journal:

Year:

2009

Language:

english

File:

PDF, 854 KB

english, 2009

10

A kinetic model of phosphofructokinase from Plasmodium berhei. Influence of ATP and fructose-6-phosphate

Detlef Buckwitz, Gisela Jacobasch, Christa Gerth, Hermann-Georg Holzhütter, Richard Thamm

Journal:

Molecular and Biochemical Parasitology

Year:

1988

Language:

english

File:

PDF, 570 KB

english, 1988

11

Mathematical modelling of the purine metabolism of the rat liver

Thomas Bartel, Hermann-Georg Holzhütter

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1990

Language:

english

File:

PDF, 659 KB

english, 1990

12

The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy

Nikolaus Berndt, Hermann-Georg Holzhütter

Journal:

Cell Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 502 KB

english, 2013

13

[Lecture Notes in Computer Science] Medical Data Analysis Volume 2868 || Isobologram Analysis in MATLAB for Combined Effects of Two Agents in Dose-Response Experiments

Perner, Petra, Brause, Rüdiger, Holzhütter, Hermann-Georg

Year:

2003

Language:

english

File:

PDF, 245 KB

english, 2003

14

-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Berndt, Nikolaus, Bulik, Sascha, Holzhütter, Hermann-Georg

Journal:

International Journal of Cell Biology

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

15

Computational Lipidology: Predicting Lipoprotein Density Profiles in Human Blood Plasma

Hübner, Katrin, Schwager, Thomas, Winkler, Karl, Reich, Jens-Georg, Holzhütter, Hermann-Georg, Bourne, Philip E.

Journal:

PLoS Computational Biology

Year:

2008

Language:

english

File:

PDF, 1.23 MB

english, 2008

16

On growth effects in the human liver

Werner, Daniel, Ricken, Tim, Holzhütter, Hermann-Georg, König, Matthias, Dahmen, Uta, Dirsch, Olaf

Journal:

Year:

2014

Language:

english

File:

PDF, 988 KB

english, 2014

17

EIN 4-KOMPARTIMENT-MODELL ZUR Ca-DYNAMIK IN DER MYOKARDZELLE

Storch, Eberhard, Günther, Joachim, Holzhütter, Hermann-Georg

Journal:

Biomedical Engineering/ Biomedizinische Technik

Year:

1991

Language:

german

File:

PDF, 387 KB

german, 1991

18

Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110

Praus, Michael, Kettelgerdes, Gerhard, Baier, Michael, Holzhütter, Hermann-Georg, Jungblut, Peter, Maissen, Manuela, Epple, Guido, Schleuning, Wolf-Dieter, Köttgen, Eckart, Aguzzi, Adriano, Geßner, Re

Journal:

Thrombosis and Haemostasis

Year:

2003

Language:

english

File:

PDF, 178 KB

english, 2003

19

In Vitro Phototoxicity Testing: Development and Validation of a New Concentration Response Analysis Software and Biostatistical Analyses Related to the Use of Various Prediction Models

Peters, Björn, Holzhütter, Hermann-Georg

Journal:

Alternatives to laboratory animals : ATLA

Year:

2002

File:

PDF, 275 KB

2002

20

Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis

Sven Knüppel, Jorge Esparza-Gordillo, Ingo Marenholz, Hermann-Georg Holzhütter, Anja Bauerfeind, Andreas Ruether, Stephan Weidinger, Young-Ae Lee, Klaus Rohde

Journal:

BMC Medical Genetics

Year:

2012

Language:

english

File:

PDF, 175 KB

english, 2012

21

Use of Mathematical Models for Predicting the Metabolic Effect of Large-Scale Enzyme Activity Alterations : Application to Enzyme Deficiencies of Red Blood Cells

Ronny Schuster, Hermann-Georg Holzhütter

Journal:

Year:

1995

Language:

english

File:

PDF, 1.50 MB

english, 1995

22

MATHEMATICAL MODELLING OF CELLULAR RESPONSES TO EXTERNAL SIGNALS

HOLZHÜTTER, HERMANN-GEORG, QUEDENAU, JÖRN

Journal:

Journal of Biological System

Year:

1995

Language:

english

File:

PDF, 727 KB

english, 1995

23

Computer Simulations Suggest a Key Role of Membranous Nanodomains in Biliary Lipid Secretion

Eckstein, Johannes, Berndt, Nikolaus, Holzhütter, Hermann-Georg, McCulloch, Andrew D.

Journal:

PLoS Computational Biology

Year:

2015

Language:

english

File:

PDF, 3.48 MB

english, 2015

24

DER EINFLUSS DES Ca2+-INDIKATORS FLUO-3 AUF DIE MYOKARDIALEN Ca2+-KONZENTRATIONEN

Storch, Eberhard, Günther, Joachim, Lammerich, Andreas, Holzhütter, Hermann-Georg

Journal:

Biomedical Engineering/ Biomedizinische Technik

Year:

1993

Language:

german

File:

PDF, 413 KB

german, 1993

25

The importance of membrane microdomains for bile salt-dependent biliary lipid secretion

Eckstein, Johannes, Holzhütter, Hermann-Georg, Berndt, Nikolaus

Journal:

Journal of Cell Science

Year:

2018

Language:

english

File:

PDF, 1.92 MB

english, 2018

26

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

Brosig, Annika, Fuchs, Joachim, Ipek, Fatih, Kroon, Cristina, Schrötter, Sandra, Vadhvani, Mayur, Polyzou, Alexandra, Ledderose, Julia, van Diepen, Michiel, Holzhütter, Hermann-Georg, Trimbuch, Thorst

Journal:

Year:

2019

Language:

english

File:

PDF, 3.41 MB

english, 2019

27

Quantification of Pathways of Glucose Utilization and Balance of Energy Metabolism of Rabbit Reticulocytes

Werner SIEMS, Marianne MÜLLER, Renate DUMDEY, Hermann-Georg HOLZHÜTTER, Jörg RATHMANN, Samuel Mitja RAPOPORT

Journal:

Year:

1982

Language:

english

File:

PDF, 896 KB

english, 1982

28

Mathematical modelling of metabolic pathways affected by an enzyme deficiency : A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells

Hermann-Georg HOLZHÜTTER, Gisela JACOBASCH, Alex BISDORFF

Journal:

Year:

1985

Language:

english

File:

PDF, 796 KB

english, 1985

29

SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques

Bölling, Christian, Weidlich, Michael, Holzhütter, Hermann-Georg

Journal:

Journal of Biomedical Semantics

Year:

2014

Language:

english

File:

PDF, 1.80 MB

english, 2014

30

Quantification of Pathways of Glucose Utilization and Balance of Energy Metabolism of Rabbit Reticulocytes : An Application of Compartmental Analysis to the Citric Acid Cycle of Rabbit Reticulocytes

Hermann-Georg HOLZHÜTTER, Werner SIEMS, Marianne MÜLLER, Samuel Mitja RAPOPORT

Journal:

Year:

1982

Language:

english

File:

PDF, 314 KB

english, 1982

31

The virtual liver: state of the art and future perspectives

Drasdo, Dirk, Bode, Johannes, Dahmen, Uta, Dirsch, Olaf, Dooley, Steven, Gebhardt, Rolf, Ghallab, Ahmed, Godoy, Patricio, Häussinger, Dieter, Hammad, Seddik, Hoehme, Stefan, Holzhütter, Hermann-Georg,

Journal:

Archives of Toxicology

Year:

2014

Language:

english

File:

PDF, 186 KB

english, 2014

32

HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology

Berndt, Nikolaus, Bulik, Sascha, Wallach, Iwona, Wünsch, Tilo, König, Matthias, Stockmann, Martin, Meierhofer, David, Holzhütter, Hermann-Georg

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 2.44 MB

english, 2018

33

Synchrotron infrared spectroscopic ellipsometry for characterization of biofunctional surfaces

Guoguang Sun, Dana Maria Rosu, Xin Zhang, Marc Hovestädt, Simona Pop, Ulrich Schade, Dennis Aulich, Michael Gensch, Bernhard Ay, Hermann-Georg Holzhütter, Dietrich R. T. Zahn, Norbert Esser, Rudolf Vo

Journal:

physica status solidi (b)

Year:

2010

Language:

english

File:

PDF, 804 KB

english, 2010

34

The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model

Nikolaus Berndt, Sabrina Hoffmann, Jan Benda, Hermann-Georg Holzhütter

Journal:

Journal of Theoretical Biology

Year:

2011

Language:

english

File:

PDF, 796 KB

english, 2011

35

The virtual liver: a multidisciplinary, multilevel challenge for systems biology

Hermann-Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M. Henney

Journal:

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 693 KB

english, 2012

36

The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism – insights from mathematical modeling

Bulik, Sascha, Holzhütter, Hermann-Georg, Berndt, Nikolaus

Journal:

Year:

2016

Language:

english

File:

PDF, 4.63 MB

english, 2016

37

A Unifying Mathematical Model of Lipid Droplet Metabolism Reveals Key Molecular Players in the Development of Hepatic Steatosis

Wallstab, Christin, Eleftheriadou, Dimitra, Schulz, Theresa, Damm, Georg, Seehofer, Daniel, Borlak, Jürgen, Holzhütter, Hermann-Georg, Berndt, Nikolaus

Journal:

Year:

2017

Language:

english

File:

PDF, 1.43 MB

english, 2017

38

Dual role of oxygen during lipoxygenase reactions

Igor Ivanov, Jan Saam, Hartmut Kuhn, Hermann-Georg Holzhütter

Journal:

Year:

2005

Language:

english

File:

PDF, 388 KB

english, 2005

39

Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28–αβ and of the Sequence and Length of Polypeptides on the Degradation Kinetics

Michele Mishto, Fabio Luciani, Hermann-Georg Holzhütter, Elena Bellavista, Aurelia Santoro, Kathrin Textoris-Taube, Claudio Franceschi, Peter M. Kloetzel, Alexey Zaikin

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 840 KB

english, 2008

40

Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus

Schneider, Justus, Berndt, Nikolaus, Papageorgiou, Ismini E, Maurer, Jana, Bulik, Sascha, Both, Martin, Draguhn, Andreas, Holzhütter, Hermann-Georg, Kann, Oliver

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2017

Language:

english

File:

PDF, 1004 KB

english, 2017

41

Mathematical analysis of enzymic reaction systems using optimization principles

Reinhart HEINRICH, Stefan SCHUSTER, Hermann-Georg HOLZHÜTTER

Journal:

Year:

1991

Language:

english

File:

PDF, 2.09 MB

english, 1991

42

A Kinetic Model for the Interaction of Nitric Oxide with a Mammalian Lipoxygenase

Hermann-Georg Holzhütter, Rainer Wiesner, Jörg Rathmann, Reinhard Stösser, Hartmut Kühn

Journal:

Year:

1997

Language:

english

File:

PDF, 927 KB

english, 1997

43

Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore

Hoppe, Andreas, Ilkavets, Iryna, Dooley, Steven, Holzhütter, Hermann-Georg

Journal:

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

44

A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling

Carola Huthmacher, Christoph Gille, Hermann-Georg Holzhütter

Journal:

Journal of Theoretical Biology

Year:

2008

Language:

english

File:

PDF, 172 KB

english, 2008

45

[IMPERIAL COLLEGE PRESS Proceedings of the 7th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2007) - Institute of Medical Science, University of Tokyo, Japan (31 July – 2 August 2007)] Genome Informatics 2007 - PRUNING GENOME-SCALE METABOLIC MODELS TO CONSISTENT AD FUNCTIONEM NETWORKS

HOFFMANN, SABRINA, HOPPE, ANDREAS, HOLZHÜTTER, HERMANN-GEORG

Language:

english

File:

PDF, 773 KB

english

46

A theoretical approach to the evolution and structural design of enzymatic networks; Linear enzymatic chains, branched pathways and glycolysis of erythrocytes

Heinrich Reinhart, Holzhütter Hermann-Georg, Schuster Stefan

Journal:

Bulletin of Mathematical Biology

Year:

1987

Language:

english

File:

PDF, 2.42 MB

english, 1987

47

Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts

BELKNER, Jutta, STENDER, Hannelore, HOLZHÜTTER, Hermann-Georg, HOLM, Cecilia, KÜHN, Hartmut

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 167 KB

english, 2000

48

Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes

Andreas Hoppe, Christine Richter, Hermann-Georg Holzhütter

Journal:

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

49

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome

Bech-Otschir, Dawadschargal, Helfrich, Annett, Enenkel, Cordula, Consiglieri, Gesa, Seeger, Michael, Holzhütter, Hermann-Georg, Dahlmann, Burkhardt, Kloetzel, Peter-Michael

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 525 KB

english, 2009

50

A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes

Peter LUDWIG, Hermann-Georg HOLZHÜTTER, Alfredo COLOSIMO, Maria Chiara SILVESTRINI, Tankred SCHEWE, Samuel M. RAPOPORT

Journal:

Year:

1987

Language:

english

File:

PDF, 1.15 MB

english, 1987

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